Dosage; Usual; Oral: 400 mg once daily
A dose of 400 mg once daily for 3 days is suitable in women with acute uncomplicated cystitis.
For surgical infection prophylaxis a single 400 mg dose is given 1 to 6 hours before the procedure.
Brands
| Brand Name | Manufacturer Name | Distributor | Drug Strength | Packaging | Formulation | Formulation Strength | Price |
|---|---|---|---|---|---|---|---|
| Lomebac | Popular Pharmaceuticals Ltd | Madawa Pharmaceuticals Ltd. | 0.30% | 5ml | eye drops | per ml | KES 160 |
| Lomflox | IPCA | Sai Pharmaceuticals Ltd. | 400mg | 5 | Tablet | per tablet | KES 352.00 |
| Mode Of Action | interferes with bacterial DNA synthesis by inhibiting topoisomerase II (DNA gyrase) and topoisomerase IV. |
|---|---|
| Drug Indication | Bacterial eye infections |
| Drug Category | OPHTHALMIC DRUGS |
| Drug Sub-Category | Antibacterial ophthalmic drugs |
Moxifloxacin more information
| Lomefloxacin | |
|---|---|
| Mode Of Action | interferes with bacterial DNA synthesis by inhibiting topoisomerase II (DNA gyrase) and topoisomerase IV. |
| Drug Indication | E.N.T., UTI, RTI, skin and soft tissues, bone, joint, GI, intra-abdominal, pelvic and severe infections, gonorrhoea. |
| Precautions | A relatively high incidence of phototoxic reactions has been seen in patients taking lomefloxacin. Patients should be advised to avoid exposure to sunlight during, and for a few days after, lomefloxacin therapy, and to stop the drug immediately if phototoxicity occurs. Risk of phototoxicity may be reduced by taking lomefloxacin in the evening. |
| Contra-Indications | History of tendon disorders related to quinolone use, documented hypersensitivity. |
| Side Effects | High incidence of photosensitivity, local irritation at the site of injection, GI disturbances, dizziness, headache, tremor, confusion, convulsions, rashes, blurred vision, psychotic reactions, impaired vision, impaired taste and smell sensation, Stevens-Johnson syndrome, hot flushes, skin rashes, migraine. |
| Dosage | Usual dose is 400 mg once daily for 10 to 14 days. A dose of 400 mg once daily for 3 days is suitable in women with acute uncomplicated cystitis.For surgical infection prophylaxis a single 400 mg dose is given 1 to 6 hours before the procedure. |
| Pregnancy Category | Category B3 |
| Pregnancy Category Description | Drugs which have been taken by only a small number of pregnant women and women of child-bearing age with no any established rise in the frequency of malformations or other direct or indirect detrimental effects on the foetus having been noted. Studies in animals show evidence of an increased occurrence of foetal damage, the significance of which is uncertain in human |
| Drug Category | DRUGS ACTING ON INFECTIONS |
| Drug Sub-Category | Fluoroquinolones |